Carl Zimmer, Sunil Kumar Aggarwal and Nathan Sackett speak on stage during the Crosscut Ideas Festival in Seattle on May 6, 2023.

Carl Zimmer, Sunil Kumar Aggarwal and Nathan Sackett speak on stage during the Crosscut Ideas Festival in Seattle on May 6, 2023.

Psychedelics are moving back into the mainstream. According to a growing body of medical research, psychedelic drugs such as psilocybin and ketamine can have a profound impact on people struggling with mental health conditions, including depression, post-traumatic stress and substance-use disorders.

As a result, legal barriers are beginning to fall away. The U.S. Food and Drug Administration has designated psilocybin as a “breakthrough therapy,” for example, accelerating its path to approval, and recently released draft guidance for all clinical trials with psychedelic drugs.


Subscribe to Crosscut Talks on Apple PodcastsSpotifyStitcher, or Podbean.


For this episode of the Crosscut Talks podcast, we listen in on a conversation among science journalist and author Carl Zimmer, palliative and rehabilitative care physician Dr. Sunil Kumar Aggarwal and University of Washington psychiatry professor Dr. Nathan Sackett about the rapidly emerging field of psychedelics in psychotherapy.

They discuss these drugs’ specific effects on the brain, explain their use in clinical practice and in current research and explore some of the bigger questions raised — from the challenges of practicing medicine in a legal gray area to the nature of human consciousness.

Latest Blog Posts

AIMS INSTITUTE’S COGNITIVE DECLINE PROTOCOL

AIMS INSTITUTE’S COGNITIVE DECLINE PROTOCOL

LJ STANDISH AND DAVID JAMES Dr. Standish and her team can help improve brain function, improve memory and slow cognitive decline in Alzheimer’s disease.  Please make an appointment to start.  Call 206-420-1321.  Scientific Rationale A protocol incorporating low-dose lithium orotate, Lion’s Mane mushroom extract, NADH, transcranial magnetic stimulation (TMS), and blood sugar regulation counseling is scientifically rational for treating cognitive decline based on mechanistic, preclinical, and emerging human studies. Low-Dose Lithium Orotate (5 mg/day) Recent brain tissue studies link low brain lithium to the onset and progression of Alzheimer’s disease, with deficiency accelerating synaptic loss and cognitive decline. Low-dose lithium orotate has ...

Read More
One Doctor’s Campaign to Let the Dying Take Psychedelics

One Doctor’s Campaign to Let the Dying Take Psychedelics

Psilocybin mushrooms on a dehydrator tray. Photographer: Jason Connolly/AFP/Getty Images By Charles Gorrivan September 3, 2025 at 3:00 AM PDT Corrected September 3, 2025 at 9:04 AM PDT Hi, it’s Charles in New York. When Brave New World author Aldous Huxley was on his deathbed in 1963, his wife injected him with two doses of LSD, the powerful psychedelic, as he slipped away. Was Huxley on to something? More on that in a moment, but first … Today’s must-reads RFK Jr. set new priorities for the CDC after firing its director. A big Danish pension fund bets that Novo Nordisk ...

Read More
Call Us Text Us
Skip to content